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KMID : 0369820100400030161
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Jorunal of Korean Pharmaceutical Sciences
2010 Volume.40 No. 3 p.161 ~ p.166
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Development of Fast Dissolving Tablet Containing Herb Extract by Freeze-Drying Technique
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Kim Jae-Il
Choi Hoo-Kyun
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Abstract
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A fast dissolving tablet was developed using the freeze-drying technique. Hyeonggaeyeongyotang was selected as a model oriental medicine. Formulation and processing parameters were studied to obtain freeze-dried tablet with high drug loading, good palatability, and fast disintegration time. Kollidon®CLM served as both matrix former and taste masking agent. Ethanol used as co-solvent, decreased the disintegration time of tablet. Aspartame was employed to impart better taste. Drying condition was found to have a major effect in the morphology of the tablets. Freeze-drying process was optimized to decrease the processing time and improve the appearance of the tablets.
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KEYWORD
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Fast dissolving tablet, Oriental medicine, Crosspovidone, Freeze-drying, Hyeonggaeyeongyotang
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